About

Target 2035 is an open science global movement consisting of international scientists and researchers, focusing on the creation of chemical and biological tools to study human proteins and inform drug discovery.

Mission

Target 2035 aims to develop a pharmacological modulator for every protein in the human proteome by 2035. These chemical and biological reagents (called chemical or biological probes) can then be used to modulate and understand protein function and reveal novel therapeutic targets for tomorrow’s medicines.

Vision

By fostering collaboration between scientists and researchers globally we will create open access tools to study each human protein and gene.

Read more on why and how to enable research on the dark genome:

Ackloo, S. et al. (2021) CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding. ChemRxiv. https://doi.org/10.33774/chemrxiv-2021-rzq4n
Müller, S. et al. (2021) Target 2035 - update on the quest for a probe for every protein, RSC Med. Chem., https://doi.org/10.1039/D1MD00228G
Carter, A.J. et al. (2019) Target 2035: probing the human proteome, Drug Discov Today, https://doi.org/10.1016/j.drudis.2019.06.020
Mullard A. (2019) A probe for every protein Nat. Rev. Drug Discov https://doi.org/10.1038/d41573-019-00159-9
Oprea, T.I. et al. (2018) Unexplored therapeutic opportunities in the human genome. Nat. Rev. Drug Discov. 17, 317–332, https://doi.org/10.1038/nrd.2018.14
Stoeger, T. et al. (2018) Large-scale investigation of the reasons why potentially important genes are ignored. PLoS Biol. 16 e2006643 https://doi.org/10.1371/journal.pbio.2006643
Oprea, T.I. et al. (2018) Far away from the lamppost. PLoS Biol. 16 e3000067 https://doi.org/10.1371/journal.pbio.3000067
Arrowsmith, C.H. et al. (2015) The promise and peril of chemical probes. Nat. Chem. Biol. 11, 536–541 https://doi.org/10.1038/nchembio.1867
Edwards, A. (2011) Too many roads not taken. Nature 470, 163–165 https://doi.org/10.1038/470163a
Fedorov, O. et al. (2010) The (un)targeted cancer kinome. Nat. Chem. Biol. 6, 166–169 https://doi.org/10.1038/nchembio.297