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Read more on why and how to enable research on the dark genome:

• Ackloo, S. et al. (2022) CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding. Nat. Rev. Chemistry. https://www.nature.com/articles/s41570-022-00363-z

• Müller, S. et al. (2021) Target 2035 - update on the quest for a probe for every protein. RSC Med. Chem., https://doi.org/10.1039/D1MD00228G

• Carter, A.J. et al. (2019) Target 2035: probing the human proteome. Drug Discov Today, https://doi.org/10.1016/j.drudis.2019.06.020

• Mullard A. (2019) A probe for every protein Nat. Rev. Drug Discov https://doi.org/10.1038/d41573-019-00159-9

• Oprea, T.I. et al. (2018) Unexplored therapeutic opportunities in the human genome. Nat. Rev. Drug Discov. 17, 317–332, https://doi.org/10.1038/nrd.2018.14

• Stoeger, T. et al. (2018) Large-scale investigation of the reasons why potentially important genes are ignored. PLoS Biol. 16 e2006643 https://doi.org/10.1371/journal.pbio.2006643

• Oprea, T.I. et al. (2018) Far away from the lamppost. PLoS Biol. 16 e3000067 https://doi.org/10.1371/journal.pbio.3000067

• Arrowsmith, C.H. et al. (2015) The promise and peril of chemical probes. Nat. Chem. Biol. 11, 536–541 https://doi.org/10.1038/nchembio.1867

• Edwards, A. (2011) Too many roads not taken. Nature 470, 163–165 https://doi.org/10.1038/470163a

• Fedorov, O. et al. (2010) The (un)targeted cancer kinome. Nat. Chem. Biol. 6, 166–169 https://doi.org/10.1038/nchembio.297