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Chemoproteomic profiling: from target discovery to target engagement

March 16, 2021, 10:00 am EDT / 3:00 pm CEST

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Program

Host and moderator: Jordan Meier (National Cancer Institute, NIH)

5 min
Jordan Meier (National Cancer Institute, NIH)
Welcome and introduction
20 min
Ekaterina Vinogradova (Rockefeller University)
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human Immune Cells
20 min
Christopher Parker (The Scripps Research Institute) 
Chemoproteomic Ligand and Target Discovery in Cells
20 min
Kilian Huber (University of Oxford)
Global Target Engagement and Selectivity Profiling Using Chemoproteomic Approaches
10 min
Jordan Meier (National Cancer Institute, NIH)
Panel Discussion & Close 

BIO SKETCHES

Headshot of Jordan Meier

Jordan Meier (National Cancer Institute, NIH)

Jordan Meier is Senior Investigator and Head of the Epigenetics and Metabolism Section within the Chemical Biology Laboratory in the Center of Cancer Research of the NCI. His work focuses on the development of chemical approaches to study epigenetic signaling and its relationship to cellular metabolism. The goal of his studies is to better elucidate the underlying logic linking gene expression and metabolism, and apply this knowledge towards new approaches to cancer therapy, diagnosis, and chemoprevention.

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Ekaterina Vinogradova (Rockefeller University) 

Ekaterina (Katya) Vinogradova is an Assistant Professor at Rockefeller University and Head of Laboratory of Chemical Immunology and Proteomics. Her group develops and applies innovative chemical proteomic profiling technologies, with the aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system and how those differences can be further leveraged from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells.

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Christopher Parker (The Scripps Research Institute)

Christopher Parker is Assistant Professor in the Department of Chemistry at Scripps Research Institute. His team seeks to develop chemistry-enabled strategies to investigate human biology and disease pathology by integrating organic synthesis with chemical proteomics and cell/molecular biology. His primary objective is not only to better understand protein function and corresponding disease roles, but also to create chemical tools and technologies that might facilitate the development of new therapeutics.

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Headshot of Kilian Huber

Kilian Huber (University of Oxford)

Kilian joined the SGC in 2015 as Principal Investigator and in 2019 assumed the Senior Chemical Biology Group Leader position at the Centre for Medicines Discovery (CMD). He has received several awards including GSK Discovery Fast Track Challenge Award in 2014 and a Young Investigator Award of the German Pharmaceutical Society (DPhG-Stiftung/Horst-Böhme-Stiftung) in 2015. Kilian’s main research interests comprise the functional exploration of cellular signaling networks by the development of specific chemical probes and chemical biology approaches apt to identify new therapeutic targets relevant for the treatment of human disease.

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