JOIN THE EFFORT

Previous Webinar

Covalent ligand discovery for chemical probes to challenging targets

February 16, 2021, 10:00 am EDT / 4:00 pm CEST

Watch Webinar

Program

Host and moderator: Alex Bullock (University of Oxford)

5 min
Alex Bullock (University of Oxford)
Welcome and introduction
20 min
Keriann Backus (UCLA)
Expanding the activity-based chemoproteomic toolbox
20 min
Nir London (Weizmann Institute of Science) 
Teaching acrylamides new tricks 
20 min
Nicolas Moitessier (Molecular Forecaster)
Docking covalent drugs using FITTED: Development & Applications to Serine Protease Inhibitors
10 min
Alex Bullock (University of Oxford)
Panel Discussion & Close 

BIO SKETCHES

Headshot of Alex Bullock

Alex Bullock (Centre for Medicines Discovery, University of Oxford) 

Alex Bullock trained at the University of Cambridge in biochemistry. His PhD research under the mentorship of Sir Alan Fersht characterised the folding and stability of mutant p53 and stimulated efforts to identify chemical chaperones that rescued mutant p53 activity in cancer cells. He was subsequently awarded a Wellcome Trust International Prize Travelling Research Fellowship, which he began in the group of David Baker at the University of Washington, Seattle.

Read more

Keriann Backus (UCLA)

Keriann Backus (UCLA)

Keriann M. Backus, Ph.D., is an Assistant Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA and an Assistant Professor of Chemistry and Biochemistry at UCLA. Dr. Backus received her B.S. in Chemistry and B.A. in Latin American Studies from Brown University in 2007. She conducted undergraduate research in inorganic chemistry at Brown in the laboratory of Amit Basu on the synthesis and characterization of metal coordinating 1,2,3-triazoles. As part of her undergraduate education, she also conducted research in the laboratory of Tarun Kapoor at Rockefeller University. As a 2007 Rhodes Scholar and an NIH Oxford Cambridge Scholar, her Ph.D.

Read more

Headshot of Nir London

Nir London (Weizmann Institute of Science)

Nir London is an assistant prof. at the Weizmann Institute of Science. His lab is focused on covalent chemical biology and drug discovery and has developed several technologies for the design of covalent inhibitors, and their application as chemical probes against challenging targets. These include covalent docking, covalent fragment screening, and computational covalent derivatization. More recently, the lab is also developing covalent PROTACs and additional protein proximity inducers. 

Read more

headshot of Nicolas Moitessier

Nicolas Moitessier (Molecular Forecaster)

Nicolas Moitessier is Professor of Chemistry at McGill University and co-founder and CSO of Molecular Forecaster. His research interests lie at the interface of computational chemistry and medicinal chemistry including software development, machine learning, development of quantum mechanical techniques but also organic and asymmetric synthesis, medicinal chemistry and biochemistry.

Read more