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Drugging the Undruggable: Targeted Protein Degradation as Medicine

April 5, 2022, 10:00 am EDT / 4:00 pm CEST

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Program

Host and moderator: Biological Discovery through Chemical Innovation (BDCI) initiative at Emory University

10 min
BDCI, Emory University
Welcome and introduction
25 min
Georg Winter (CeMM)
Identification and characterization of molecular glue degraders
25 min
Danette Daniels (Foghorn Therapeutics)
Considerations for validating degraders and bringing them into the clinic

BIO SKETCHES

Headshot of Georg Winter

Georg Winter (CeMM)

Georg Winter is Principal Investigator at CeMM as well as co-founder of the biotech companies Proxygen and Solgate. In his lab at CeMM he is focusing on targeted protein degradation and especially on molecular glue degraders as these molecules cause the complete elimination of harmful proteins and constitute a new avenue towards targeting proteins that were previously considered “undruggable”. His lab connects basic research in gene regulation and the ubiquitin-proteasome system with functional genomics and chemical probe development to develop novel and personalized therapeutic paradigms.

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Headshot of Danette Daniels

Danette Daniels (Foghorn Therapeutics)

Danette Daniels is Vice President of the Protein Degrader Platform at Foghorn Therapeutics which she joined recently. She was an early leader in the field of targeted protein degradation, pioneering approaches to monitor cellular kinetics of degradation and most recently, co-developing a new PROTAC modality. Prior to joining Foghorn Therapeutic Danette has been R&D Group Leader of Functional Proteomics at Promega Corporation.

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