Previous Webinar
Drugging the Undruggable: Targeted Protein Degradation as Medicine
April 5, 2022, 10:00 am EDT / 4:00 pm CEST
Watch WebinarProgram
Host and moderator: Biological Discovery through Chemical Innovation (BDCI) initiative at Emory University
10 min
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BDCI, Emory University
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Welcome and introduction
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25 min
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Georg Winter (CeMM)
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Identification and characterization of molecular glue degraders
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25 min
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Danette Daniels (Foghorn Therapeutics)
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Considerations for validating degraders and bringing them into the clinic
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BIO SKETCHES
Georg Winter (CeMM)
Georg Winter is Principal Investigator at CeMM as well as co-founder of the biotech companies Proxygen and Solgate. In his lab at CeMM he is focusing on targeted protein degradation and especially on molecular glue degraders as these molecules cause the complete elimination of harmful proteins and constitute a new avenue towards targeting proteins that were previously considered “undruggable”. His lab connects basic research in gene regulation and the ubiquitin-proteasome system with functional genomics and chemical probe development to develop novel and personalized therapeutic paradigms.
Danette Daniels (Foghorn Therapeutics)
Danette Daniels is Vice President of the Protein Degrader Platform at Foghorn Therapeutics which she joined recently. She was an early leader in the field of targeted protein degradation, pioneering approaches to monitor cellular kinetics of degradation and most recently, co-developing a new PROTAC modality. Prior to joining Foghorn Therapeutic Danette has been R&D Group Leader of Functional Proteomics at Promega Corporation.