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Chemical probes

What is a Chemical Probe

A chemical probe is simply a reagent—a selective small-molecule modulator of a protein's function that allows the user to ask mechanistic and phenotypic questions about its molecular target in biochemical, cell-based or animal studies. Additional references may be found on the Chemical Probes Portal.

Chemical Probe Stories

Open access chemical probes have an impact on preclinical research! Find out how by reading the chemical probe stories below.

PFI-653, a chemical probe for Vanin-1, a target in Inflammatory Bowel Disease

PFI-653 and its negative control can be used to explore the role of VNN-1 in inflammatory and other diseases

Inhibition of type I PRMTs

Chemical probe MS023: Inspiration for the development of clinical candidates

Studying inflammatory diseases with a chemical probe for IRAK4

Inflammation and IRAK4: the chemical probe GNE-2256

KAT6A Inhibition

The chemical probe WM-1119 allows to test the role of KAT6A in different cancers

DRAK1 inhibition

The chemical probe CK156 enables exploration of the role of DRAK1 in different cancers